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How can transdermal cannabinoid patches be made more bioavailable while minimizing the risk of skin irritation or other adverse effects?

How can transdermal cannabinoid patches be made more bioavailable while minimizing the risk of skin irritation or other adverse effects? Enhancing bioavailability can be achieved by incorporating skin penetration enhancers, optimizing cannabinoid formulations, and ensuring patch materials are gentle on the skin. It’s important to avoid harsh chemicals that could cause irritation or sensitization, instead using mild excipients and soothing compounds to balance effectiveness with skin safety. Patch designs that promote controlled, slow release also prevent over-exposure to cannabinoids, reducing the risk of irritation. Regular testing and optimization help ensure that patches are both bioavailable and skin-friendly.

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