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How do the solubility properties of cannabinoids impact their formulation in transdermal delivery systems such as patches?

How do the solubility properties of cannabinoids impact their formulation in transdermal delivery systems such as patches? Cannabinoid solubility affects how well they dissolve in the patch matrix, which directly influences their absorption through the skin. Lipophilic cannabinoids, such as CBG and CBD, are more easily incorporated into oil-based formulations, while hydrophilic cannabinoids may require different solubilizers. The solubility properties determine the need for specific excipients and the overall effectiveness of the transdermal delivery system, optimizing bioavailability.

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