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What role do terpenes play in enhancing or modifying the effects of cannabinoids in therapeutic applications?

What role do terpenes play in enhancing or modifying the effects of cannabinoids in therapeutic applications? Terpenes, the aromatic compounds found in cannabis, play a significant role in enhancing or modifying the effects of cannabinoids through the entourage effect. This phenomenon suggests that the combination of cannabinoids and terpenes can produce synergistic effects, potentially increasing therapeutic benefits while reducing side effects. For instance, certain terpenes like myrcene may enhance the sedative effects of THC, while others, like limonene, may provide uplifting effects. By carefully selecting terpenes in cannabinoid formulations, clinicians can tailor treatments to achieve desired therapeutic outcomes for specific conditions. This understanding of terpenes highlights the importance of considering the full spectrum of compounds in cannabis for optimal therapeutic applications (Russo, 2011).
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