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Welke rol speelt het endocannabinoïde systeem bij pijnbestrijding?

Wat is de rol van het endocannabinoïde systeem bij pijnbestrijding? Het endocannabinoïde systeem speelt een cruciale rol bij pijnbestrijding door pijnperceptie en -reactie te reguleren via CB1- en CB2-receptoren. CB1-receptoren, gelegen in de hersenen en het centrale zenuwstelsel, helpen pijnsignalen te moduleren door de afgifte van exciterende neurotransmitters te verminderen. CB2-receptoren, voornamelijk te vinden in perifere weefsels, beïnvloeden ontstekingen, die vaak gepaard gaan met pijn. Endocannabinoïden, zoals anandamide en 2-AG, worden door het lichaam aangemaakt als reactie op letsel of ontsteking en binden zich aan deze receptoren om ongemak te verlichten. De pijnregulatie door het endocannabinoïde systeem is essentieel voor het handhaven van homeostase en de behandeling van chronische pijn.
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