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Hvad er effekten af CBD på THC-induceret modulering af stressrelateret genekspression?

Hvad er effekten af ​​CBD på THC-induceret modulering af stressrelateret genekspression? CBD har en modulerende effekt på stressrelateret genekspression induceret af THC. THC kan aktivere CB1-receptorer og øge ekspressionen af ​​stress-responsgener såsom corticotropin-releasing hormon (CRH) og glukokortikoidreceptorer, hvilket potentielt bidrager til stress og angst. CBD kan ved at interagere med CB2-receptorer og serotonerge veje dæmpe THC's virkninger på disse gener, hvilket fører til reducerede stressreaktioner. Derudover kan CBD's neurobeskyttende egenskaber hjælpe med at genoprette balancen mellem neuroendokrin signalering og genetisk regulering involveret i stress. Denne interaktion antyder, at CBD kan være effektiv til at afbøde THC-induceret angst og stressrelateret genekspression i både akutte og kroniske stresssituationer.

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