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Hvordan påvirker CBD THC's evne til at modulere synaptisk transmission i den præfrontale cortex?

Hvordan påvirker CBD THC's evne til at modulere synaptisk transmission i den præfrontale cortex? CBD påvirker THCs effekt på synaptisk transmission i den præfrontale cortex ved at modulere CB1-receptoraktivitet. THC kan ved at aktivere CB1-receptorer i den præfrontale cortex svække synaptisk transmission, hvilket fører til kognitive underskud, herunder nedsat beslutningstagning og arbejdshukommelse. CBD fungerer imidlertid som en modulator, der reducerer overaktiveringen af ​​CB1-receptorer af THC og beskytter dermed den synaptiske funktion. Denne interaktion kan bevare kognitiv ydeevne, hvilket giver mulighed for terapeutiske effekter såsom humørregulering og angstdæmpende effekter uden at forværre kognitiv svækkelse. I kombination hjælper CBD med at stabilisere virkningerne af THC, hvilket potentielt forbedrer de terapeutiske fordele, mens kognitive bivirkninger minimeres.

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