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Kako CBD utječe na metabolizam THC-a putem enzima citokroma P450?

Kako CBD utječe na metabolizam THC-a putem enzima citokroma P450? CBD utječe na metabolizam THC-a interakcijom s enzimima citokroma P450, posebno CYP3A4 i CYP2C9, koji su uključeni u razgradnju oba kanabinoida. CBD može inhibirati aktivnost ovih enzima, što dovodi do smanjenog metabolizma THC-a. To može rezultirati produljenim ili pojačanim učincima THC-a, budući da u višim koncentracijama ostaje duže u tijelu. Inhibicija enzima CYP450 također može utjecati na metabolizam drugih lijekova koje obrađuju isti enzimi, potencijalno povećavajući njihove serumske razine i učinke. Ova interakcija zahtijeva pažljivo razmatranje kada se kombinira THC i CBD s drugim lijekovima kako bi se izbjegle štetne interakcije lijekova.

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