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Kako THC i CBD različito moduliraju endokanabinoidni sustav u neurodegenerativnim bolestima?

Kako THC i CBD različito moduliraju endokanabinoidni sustav u neurodegenerativnim bolestima? THC i CBD različito moduliraju endokanabinoidni sustav u neurodegenerativnim bolestima djelujući na CB1 i CB2 receptore s različitim učincima. THC, kao djelomični agonist na CB1 receptorima, može pospješiti neuroprotekciju aktivacijom neuroplastičnosti, ali također može doprinijeti kognitivnim oštećenjima s produljenom upotrebom. Nasuprot tome, CBD djeluje kao agonist CB2 receptora i negativni alosterički modulator CB1 receptora, što bi moglo pomoći u smanjenju neuroupale i oksidativnog stresa povezanih s bolestima poput Alzheimerove i Parkinsonove bolesti. Učinci CBD-a na neuroinflamaciju mogu poboljšati njegov terapeutski potencijal za ova stanja. Iako potencijal THC-a za neuroprotektivne prednosti postoji, protuupalna i antioksidativna svojstva CBD-a su istaknutija u tim neurodegenerativnim kontekstima.

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