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Kako THC stupa u interakciju s nekanabinoidnim receptorima, kao što su GPR55 i TRPV1?

Kako THC stupa u interakciju s nekanabinoidnim receptorima, kao što su GPR55 i TRPV1? THC također stupa u interakciju s GPR55, receptorom vezanim za G protein koji je uključen u modulaciju boli, upale i metabolizma kostiju. Aktivacija GPR55 pomoću THC-a može pojačati njegove analgetske učinke, ali točna uloga ovog receptora u psihoaktivnim učincima THC-a još se proučava. Dodatno, THC se veže na TRPV1 receptore, koji su uključeni u osjećaj boli, termoregulaciju i upalu. Kroz aktivaciju TRPV1, THC može proizvesti analgeziju i smanjiti upalu. Ove interakcije mogu pomoći u objašnjenju širih terapeutskih učinaka THC-a izvan njegovog primarnog djelovanja na endokanabinoidni sustav.

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