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Koji su metabolički putovi putem kojih CBD utječe na zdravlje jetre i kako se ti putovi razlikuju od onih na koje utječe THC?

Koji su metabolički putovi putem kojih CBD utječe na zdravlje jetre i kako se ti putovi razlikuju od onih na koje utječe THC? CBD utječe na zdravlje jetre kroz različite metaboličke putove, osobito one povezane s oksidativnim stresom i upalom. Aktivira put Nrf2, povećavajući antioksidativni kapacitet jetre i smanjujući štetu uzrokovanu slobodnim radikalima. Dodatno, CBD utječe na jetrene enzime uključene u detoksikaciju, poput enzima citokroma P450, utječući na metabolizam različitih spojeva, uključujući lijekove i toksine. Za razliku od THC-a, koji prvenstveno utječe na jetru putem aktivacije CB1 receptora, učinci CBD-a su manje psihoaktivni i uključuju izravnije antioksidativno i protuupalno djelovanje. Ovi mehanizmi čine CBD korisnim za zdravlje jetre, posebno u stanjima kao što su nealkoholna masna bolest jetre (NAFLD) i oštećenje jetre izazvano alkoholom.

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