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Come si possono ottimizzare i cerotti ai cannabinoidi per le diverse aree della pelle, come braccia, gambe o schiena, per migliorarne l'assorbimento?

Come si possono ottimizzare i cerotti ai cannabinoidi per le diverse aree della pelle, come braccia, gambe o schiena, per migliorarne l'assorbimento? Lo spessore della pelle, l’idratazione e il contenuto lipidico variano a seconda delle regioni del corpo, influenzando la diffusione dei cannabinoidi. Le aree cutanee più sottili (ad esempio, polsi, dietro le orecchie) consentono un assorbimento più rapido, mentre le regioni più spesse (ad esempio, schiena, piante dei piedi) richiedono potenziatori di permeazione. Le formulazioni dei cerotti possono essere adattate modificando gli eccipienti per adattarli a specifici siti di applicazione. La corretta selezione del sito garantisce un assorbimento coerente dei cannabinoidi e un'efficacia terapeutica (Benson, 2005).

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