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Yetişkinlerde nöroinflamatuar yolakları modüle etmede CBG'nin CBD'den farkı nedir?

Yetişkinlerde nöroinflamatuar yolakları modüle etmede CBG'nin CBD'den farkı nedir? CBG (cannabigerol), merkezi sinir sistemindeki inflamasyonun azaltılmasında önemli bir rol oynayan CB2 reseptörlerini spesifik olarak hedefleyerek ve aktive ederek nöroinflamatuar yolların modülasyonunda CBD'den farklıdır. CBD öncelikle CB1/CB2 olmayan mekanizmalar aracılığıyla endokannabinoid sistemle etkileşime girerken, CBG'nin eylemleri bağışıklık modülasyonuna daha doğrudan bağlıdır. Her iki kanabinoid de proinflamatuar sitokinleri baskılar, ancak CBG'nin mikroglial aktivasyonu daha etkili bir şekilde azalttığı bulunmuştur. Bu farklılıklar, CBG'nin nörodejeneratif hastalıklar için daha güçlü bir anti-inflamatuar ajan olarak potansiyelini vurgulamaktadır (Brierley ve diğerleri, 2016).

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