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How do cannabinoids in patches interact with the lymphatic system, and what are the implications for systemic delivery?

How do cannabinoids in patches interact with the lymphatic system, and what are the implications for systemic delivery? Cannabinoids in transdermal patches are absorbed into the skin, where they may enter the lymphatic system before reaching the bloodstream. This route of absorption can allow cannabinoids to bypass the liver’s first-pass metabolism, leading to more efficient systemic delivery. The lymphatic system helps distribute cannabinoids throughout the body, influencing their therapeutic effects on both local and systemic conditions. The ability to enter the lymphatic system also offers a more gradual onset of effects, which can be beneficial for chronic conditions.

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