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How do cannabinoids like CBD and CBG affect local blood flow at the site of patch application?

How do cannabinoids like CBD and CBG affect local blood flow at the site of patch application? CBD and CBG can influence local blood flow by interacting with cannabinoid receptors in the skin, leading to vasodilation or vasoconstriction depending on the dose and individual response. Studies suggest CBD may promote blood flow through its anti-inflammatory effects, while CBG has been shown to have vasodilatory properties that enhance circulation. Increased local blood flow can improve the absorption of cannabinoids from the patch, enhancing their therapeutic effects. However, excessive vasodilation could also lead to faster clearance, potentially reducing the duration of effect.

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