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How does CBD influence THC’s ability to modulate the hypothalamic-pituitary-adrenal (HPA) axis in stress responses?

How does CBD influence THC’s ability to modulate the hypothalamic-pituitary-adrenal (HPA) axis in stress responses? CBD modulates THC's effects on the HPA axis by counterbalancing its psychoactive properties and influencing cortisol regulation. THC activates CB1 receptors in the hypothalamus, reducing stress but sometimes increasing anxiety at high doses. CBD mitigates this by interacting with serotonin receptors and dampening overactivation of the HPA axis, leading to more stable cortisol levels. Together, they create a balanced stress response, reducing both psychological and physiological symptoms of stress. This synergy makes their combination more effective for chronic stress conditions.
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