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Kako topljivost kanabinoida u lipidima utječe na njihovu sposobnost da prijeđu krvno-moždanu barijeru i proizvedu psihoaktivnost?

Kako topljivost kanabinoida u lipidima utječe na njihovu sposobnost da prijeđu krvno-moždanu barijeru i proizvedu psihoaktivnost? Kanabinoidi su lipofilni, što znači da se otapaju u mastima, a ne u vodi, što pomaže njihovoj sposobnosti da prijeđu krvno-moždanu barijeru (BBB). Ova topljivost u lipidima omogućuje kanabinoidima poput THC-a da se vežu na CB1 receptore u mozgu, što rezultira psihoaktivnim učincima. Zbog ovog svojstva, kanabinoidi se učinkovito pohranjuju u masnom tkivu, što dovodi do odgođenog nastupa učinaka u nekim slučajevima i pridonosi dugotrajnijoj psihoaktivnosti. Sposobnost prelaska BBB ključni je čimbenik u određivanju intenziteta i početka psihoaktivnog iskustva. Kanabinoidi s nižom topljivošću lipida mogu imati smanjenu psihoaktivnu moć zbog poteškoća u prolasku BBB.

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