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Kako učinak okruženja koji uključuje terpene i flavonoide pojačava ili ublažava psihoaktivnost kanabinoida?

Kako učinak okruženja koji uključuje terpene i flavonoide pojačava ili ublažava psihoaktivnost kanabinoida? Entourage efekt opisuje kako kanabinoidi, terpeni i flavonoidi djeluju sinergistički kako bi pojačali ili modulirali psihoaktivne učinke kanabisa. Na primjer, terpeni poput mircena mogu imati umirujući, sedativni učinak koji pojačava opuštajuća svojstva THC-a, dok limonen može pospješiti učinak podizanja raspoloženja, suprotstavljajući se nekim anksiogenim učincima THC-a. Vjeruje se da flavonoidi, iako manje proučavani, doprinose efektu okruženja utječući na farmakodinamiku kanabinoida. Kombinacija ovih spojeva može stvoriti uravnoteženije i učinkovitije iskustvo, pri čemu su psihoaktivni učinci THC-a ili pojačani ili ublaženi ovisno o specifičnom profilu terpena i flavonoida. Ova sinergija objašnjava zašto različite vrste kanabisa sa sličnim razinama THC-a mogu proizvesti različite psihoaktivne učinke.

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