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How can skin conditions like acne or eczema affect the absorption of cannabinoids from transdermal patches?

How can skin conditions like acne or eczema affect the absorption of cannabinoids from transdermal patches? Skin conditions like acne or eczema may alter the skin's permeability, potentially increasing cannabinoid absorption due to inflammation or disrupted barrier function. Conversely, damaged skin may also lead to inconsistent absorption or irritation. Formulation adjustments, such as using gentler adhesives or hydrating compounds, can improve patch performance on compromised skin. Clinically, these conditions may require tailored patch formulations for optimal therapeutic effects (Baswan et al., 2020).

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