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How can the incorporation of skin penetration enhancers affect the cannabinoid release profile in transdermal patch applications?

How can the incorporation of skin penetration enhancers affect the cannabinoid release profile in transdermal patch applications? Skin penetration enhancers can increase the permeability of the skin, allowing cannabinoids to be absorbed more efficiently. These enhancers may disrupt the skin's lipid barrier temporarily, facilitating the passage of cannabinoids like CBG and CBN into deeper layers. The use of penetration enhancers can alter the release profile, allowing for a faster onset or more controlled, sustained release depending on the formulation. While these enhancers improve absorption, they must be used carefully to prevent skin irritation or discomfort.

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