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How do cannabinoid properties like polarity and molecular weight affect the speed at which they are absorbed into the bloodstream from CBD patches?

How do cannabinoid properties like polarity and molecular weight affect the speed at which they are absorbed into the bloodstream from CBD patches? Cannabinoid polarity and molecular weight are key factors in determining absorption speed, as more lipophilic (fat-soluble) cannabinoids like CBG typically penetrate the skin more easily than hydrophilic (water-soluble) cannabinoids. Smaller molecular weight cannabinoids generally pass through the skin more quickly compared to larger molecules. A cannabinoid’s polarity influences its ability to dissolve in the skin’s lipid layers, affecting its transdermal absorption rate. Understanding these properties helps optimize patch formulations for faster or controlled absorption.

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