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How does the Endocannabinoid System help with stress response?

How does the Endocannabinoid System help with stress response? The Endocannabinoid System helps regulate the body’s response to stress by modulating the release of neurotransmitters involved in stress reactions. CB1 receptors in the brain, particularly in areas like the amygdala and hippocampus, influence the release of stress hormones such as cortisol. Endocannabinoids like anandamide are released during stressful situations to help counterbalance excessive stress responses. By binding to CB1 receptors, these endocannabinoids reduce anxiety and promote a return to homeostasis. This regulation helps mitigate the effects of chronic stress and supports emotional well-being.
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