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How does the mode of action of cannabinoids like CBG and CBN in transdermal patches differ from their effects when consumed orally or via other methods?

How does the mode of action of cannabinoids like CBG and CBN in transdermal patches differ from their effects when consumed orally or via other methods? When applied transdermally, cannabinoids like CBG and CBN interact directly with skin receptors, providing localized effects such as pain relief and anti-inflammatory action. In contrast, oral consumption involves first-pass metabolism in the liver, which alters the cannabinoid's potency and effects. Transdermal delivery offers more consistent and direct absorption, resulting in fewer digestive system-related side effects and faster onset. This method also provides sustained release, making it ideal for long-term management of conditions.

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