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How does the skin’s natural pH influence the absorption of cannabinoids from transdermal patches?

How does the skin’s natural pH influence the absorption of cannabinoids from transdermal patches? The skin’s natural pH plays a crucial role in cannabinoid absorption, as it affects the solubility and permeability of cannabinoids through the epidermis. The skin’s acidic pH (around 4.5–5.5) helps maintain its barrier function and control the absorption of lipophilic compounds like cannabinoids. If the pH of the patch formulation is too alkaline or acidic, it can disrupt the skin’s barrier or reduce cannabinoid solubility, hindering absorption. Therefore, ensuring that cannabinoid patches maintain a pH close to that of the skin helps optimize both absorption and the skin’s protective function.

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