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How does the skin's natural microbiome influence the absorption and effects of cannabinoids when applied via transdermal patches?

How does the skin's natural microbiome influence the absorption and effects of cannabinoids when applied via transdermal patches? The skin's microbiome can affect the absorption of cannabinoids by influencing the skin's barrier function and its ability to retain moisture. A balanced microbiome helps maintain skin health, which can enhance cannabinoid absorption and ensure that the patch works effectively. Imbalances in the microbiome, such as in cases of acne or dermatitis, may alter the permeability of the skin, potentially affecting how cannabinoids are absorbed. Understanding the interaction between the microbiome and cannabinoid delivery helps refine patch formulations.

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