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Hvordan kan designet af cannabinoidplastre optimeres for at øge hudens permeabilitet uden at forstyrre hudbarrieren?

Hvordan kan designet af cannabinoidplastre optimeres for at øge hudens permeabilitet uden at forstyrre hudbarrieren? Permeationsforstærkere som fedtsyrer, overfladeaktive stoffer eller mikronåle kan inkorporeres i plasterdesignet for at forbedre cannabinoidabsorptionen. Disse forstærkere forstyrrer midlertidigt stratum corneum, hvilket giver mulighed for dybere penetration af cannabinoider uden at kompromittere hudens integritet. Omhyggelig formulering sikrer, at afbrydelse af hudbarrieren er minimal og reversibel. Optimering af disse faktorer øger cannabinoids biotilgængelighed, samtidig med at hudens sundhed beskyttes (Benson, 2005).

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