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Koja je uloga CBD-a u suzbijanju kognitivnih oštećenja izazvanih THC-om kod modela starenja?

Kako CBD utječe na sposobnost THC-a da promijeni proliferaciju neuralnih matičnih stanica? CBD može ublažiti promjene izazvane THC-om u proliferaciji neuralnih matičnih stanica moduliranjem endokanabinoidnog sustava, osobito njegovom interakcijom s CB2 receptorima. Pokazalo se da THC inhibira proliferaciju neuralnih matičnih stanica, potencijalno oštećujući neurogenezu u regijama poput hipokampusa. CBD, međutim, može ublažiti ovaj učinak promicanjem preživljavanja stanica i neurogeneze, djelomice svojim antioksidativnim i protuupalnim svojstvima. Ovo sugerira da CBD može pomoći u očuvanju neuroplastičnosti i regeneraciji mozga, što bi moglo biti važno za liječenje stanja povezanih sa smanjenom neurogenezom, kao što su depresija i neurodegenerativne bolesti. Zajedno, THC i CBD mogu imati suprotne učinke na živčane matične stanice, pri čemu CBD štiti od inhibitornog utjecaja THC-a.

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