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How can the delivery rate of cannabinoids in a transdermal patch be optimized for conditions requiring long-term, sustained relief, such as chronic pain?

How can the delivery rate of cannabinoids in a transdermal patch be optimized for conditions requiring long-term, sustained relief, such as chronic pain? To optimize cannabinoid delivery for conditions requiring long-term, sustained relief like chronic pain, patches can be designed with slow-release mechanisms that regulate the continuous diffusion of cannabinoids over an extended period. These systems may include matrix-based patches, microreservoirs, or rate-controlled membranes that release cannabinoids gradually, maintaining therapeutic levels without peaks and troughs. Additionally, incorporating cannabinoids with longer half-lives, such as CBD, can contribute to prolonged relief. The patch material can also be designed to be flexible and comfortable, ensuring consistent contact with the skin during wear.

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