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How do cannabinoid interactions with CB1 and CB2 receptors in the skin influence their therapeutic effects in transdermal patch formulations?

How do cannabinoid interactions with CB1 and CB2 receptors in the skin influence their therapeutic effects in transdermal patch formulations? CB1 and CB2 receptors are present in the skin, and cannabinoid interactions with these receptors can modulate inflammatory responses, pain signaling, and skin cell regeneration. When cannabinoids like CBD, CBG, or CBN are delivered through transdermal patches, they interact with these receptors to provide localized therapeutic effects, such as pain relief or reduced inflammation. CB2 receptors, in particular, play a key role in the immune response, while CB1 receptors are involved in modulating pain. This interaction enhances the overall efficacy of transdermal cannabinoid therapies.

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