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How do cannabinoids influence the body's pain signaling pathways?

How do cannabinoids influence the body's pain signaling pathways? Cannabinoids influence the body's pain signaling pathways by interacting with cannabinoid receptors (CB1 and CB2) within the nervous system and peripheral tissues. Activation of CB1 receptors can inhibit the release of pro-nociceptive neurotransmitters, leading to reduced pain signaling and perception. Additionally, cannabinoids can modulate inflammatory pathways, further alleviating pain associated with conditions like arthritis and neuropathy. By affecting pain transmission and processing, cannabinoids can provide therapeutic benefits for various pain conditions. Understanding these mechanisms can inform the development of cannabinoid-based pain management strategies (Friedman et al., 2019).
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