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How do physical characteristics of cannabinoids, such as vapor pressure or melting point, influence their incorporation into transdermal patch formulations?

How do physical characteristics of cannabinoids, such as vapor pressure or melting point, influence their incorporation into transdermal patch formulations? The vapor pressure and melting point of cannabinoids influence their ability to remain stable and effective in transdermal formulations. Cannabinoids with lower vapor pressures and higher melting points are generally more stable and easier to incorporate into patch formulations without volatilizing or degrading at room temperature. High melting points also reduce the risk of cannabinoids becoming too liquid or unstable in the patch. Understanding these properties allows formulators to select the most suitable cannabinoids and design patches that provide consistent, controlled release.

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