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How does CBD interact with cannabinoid receptors compared to THC, and what are the implications for its therapeutic use?

How does CBD interact with cannabinoid receptors compared to THC, and what are the implications for its therapeutic use? CBD interacts with cannabinoid receptors in a unique way compared to THC, as it does not directly activate CB1 receptors but rather acts as a negative allosteric modulator, which can dampen the psychoactive effects of THC. Additionally, CBD has a higher affinity for other receptors, such as serotonin and vanilloid receptors, which may contribute to its anxiolytic and anti-inflammatory properties. This differential interaction means that CBD can be used therapeutically without producing the intoxicating effects associated with THC, making it a promising option for treating conditions like anxiety, epilepsy, and chronic pain. The ability of CBD to interact with multiple receptor systems enhances its therapeutic potential and highlights its role in developing cannabinoid-based therapies (Russo, 2011).
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