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Kako CBD utječe na sposobnost THC-a da modulira hormone koji reguliraju apetit?

Kako THC i CBD međusobno djeluju kako bi utjecali na emocionalne reakcije u paradigmama uvjetovanja straha? THC i CBD međusobno djeluju kako bi utjecali na emocionalne reakcije u paradigmama uvjetovanja straha modulirajući regije mozga uključene u regulaciju emocija, kao što su amigdala i prefrontalni korteks. THC, svojom aktivacijom CB1 receptora, može promijeniti emocionalne reakcije pojačavanjem straha i tjeskobe kod nekih pojedinaca, osobito u većim dozama. CBD, s druge strane, ima anksiolitička svojstva koja se mogu suprotstaviti anksioznosti izazvanoj THC-om utječući na serotoninske receptore i smanjujući neuralnu hiperaktivnost u moždanim krugovima povezanim sa strahom. Kombinacija oba kanabinoida može pružiti uravnotežen pristup, gdje CBD ublažava potencijal THC-a da poveća strah ili tjeskobu, nudeći terapijski potencijal za anksiozne poremećaje. Ova dinamika sugerira da je omjer THC-a i CBD-a ključan u određivanju emocionalnih ishoda u takvim paradigmama.

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