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Kako THC i CBD utječu na interakcije astrocita i neurona u mozgu?

Kako THC i CBD utječu na interakcije astrocita i neurona u mozgu? THC i CBD utječu na interakcije astrocita i neurona modulirajući aktivnost astrocita, koji imaju ključnu ulogu u potpori neurona, održavanju homeostaze i reguliranju razina neurotransmitera. THC prvenstveno aktivira CB1 receptore, što dovodi do promjena u funkcijama glijalnih stanica, uključujući otpuštanje glutamata i drugih signalnih molekula koje mogu utjecati na aktivnost neurona. Nasuprot tome, čini se da CBD ima neuroprotektivne učinke smanjenjem oksidativnog stresa i promicanjem otpuštanja neurotrofnih čimbenika koji pogoduju i neuronima i astrocitima. Zajedno, THC i CBD mogu utjecati na ravnotežu ekscitacijskih i inhibitornih signala između neurona i astrocita. Ova dinamička interakcija može igrati ulogu u stanjima kao što su neurodegenerativne bolesti, gdje je disfunkcija astrocita uobičajena.

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