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Come interagisce il THC con i farmaci metabolizzati dal sistema del citocromo P450?

Come interagisce il THC con i farmaci metabolizzati dal sistema del citocromo P450? Il THC viene metabolizzato dal sistema enzimatico del citocromo P450 (CYP450), in particolare CYP2C9 e CYP3A4, che metabolizzano anche vari farmaci. Questa interazione può portare a interazioni farmacologiche, in cui il THC può alterare il metabolismo di altri farmaci, aumentandone o diminuendone gli effetti. Ad esempio, il THC può inibire il metabolismo di farmaci come il warfarin, aumentando il rischio di sanguinamento. Al contrario, il THC può favorire la degradazione delle benzodiazepine, riducendone potenzialmente gli effetti sedativi. I pazienti che utilizzano farmaci metabolizzati dagli enzimi CYP450 dovrebbero essere cauti quando li combinano con il THC a causa del rischio di alterata efficacia del farmaco e di effetti collaterali.

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