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Come si confronta l’uso dei cerotti con cannabinoidi rispetto ai metodi orali in termini di concentrazioni plasmatiche di picco e finestra terapeutica?

Come si confronta l’uso dei cerotti con cannabinoidi rispetto ai metodi orali in termini di concentrazioni plasmatiche di picco e finestra terapeutica? I cerotti ai cannabinoidi forniscono concentrazioni plasmatiche più stabili e prolungate rispetto ai metodi orali, che sono soggetti al metabolismo di primo passaggio nel fegato. La via transdermica consente ai cannabinoidi di entrare gradualmente nel flusso sanguigno, portando ad un effetto terapeutico più consistente. Questo rilascio costante dai cerotti può ampliare la finestra terapeutica e ridurre il rischio di fluttuazioni della dose, comuni con i prodotti a base di CBD per via orale. La somministrazione orale può determinare picchi di concentrazione plasmatica più elevati, ma può causare fluttuazioni più pronunciate negli effetti terapeutici, soprattutto con dosaggi irregolari.

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