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Does CBD work directly on the brain to affect the Endocannabinoid System?

Does CBD work directly on the brain to affect the Endocannabinoid System? Yes, CBD works directly on the brain by interacting with cannabinoid receptors in the central nervous system, primarily CB1 receptors. However, CBD has a low affinity for CB1 receptors, meaning it does not activate them in the same way as THC. Instead, CBD modulates the ECS by influencing the levels of endocannabinoids like anandamide, which can help reduce anxiety, promote relaxation, and regulate mood. It also impacts serotonin receptors, which are involved in mood regulation and emotional responses. Through these interactions, CBD indirectly affects brain function, helping to restore balance in the ECS and improve mental well-being.
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