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How do cannabinoid patches affect local circulation and blood flow at the site of application?

How do cannabinoid patches affect local circulation and blood flow at the site of application? Some cannabinoids, like CBD, have vasodilatory effects that may increase local blood flow. Increased circulation can enhance systemic absorption but may also affect localized therapeutic actions. The adhesive and occlusive nature of patches can slightly impact microcirculation. Further studies are needed to assess long-term effects on blood flow dynamics (Baswan et al., 2020).

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