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How do cannabinoids affect skin permeability and barrier function when applied in patch form?

How do cannabinoids affect skin permeability and barrier function when applied in patch form? Cannabinoids can interact with skin receptors and affect skin permeability by modulating the function of the skin’s barrier. Cannabinoids like CBD and CBG may enhance the permeability of the stratum corneum, allowing for better diffusion of therapeutic agents. However, excessive use or high concentrations could potentially disrupt the skin barrier, leading to dryness or irritation. The formulation of the patch can be adjusted to include moisturizing or barrier-repairing ingredients to maintain healthy skin function while optimizing cannabinoid absorption.

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