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How do cannabinoids interact with the Endocannabinoid System to regulate sleep?

How do cannabinoids interact with the Endocannabinoid System to regulate sleep? Cannabinoids interact with the Endocannabinoid System to regulate sleep by modulating the activity of CB1 and CB2 receptors in the brain and peripheral tissues. Cannabinoids like CBD and THC can influence the release of neurotransmitters involved in sleep regulation, such as serotonin and GABA, promoting relaxation and drowsiness. CBD, in particular, helps reduce anxiety and stress, common contributors to sleep disturbances, and supports the body’s natural sleep-wake cycle. Through these mechanisms, cannabinoids help improve sleep quality and duration by promoting relaxation and reducing sleep-related anxiety. This interaction helps restore healthy sleep patterns.
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