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How do cannabinoids like CBG and CBN interact with the skin microbiome, and how might this influence their therapeutic effects when applied topically?

How do cannabinoids like CBG and CBN interact with the skin microbiome, and how might this influence their therapeutic effects when applied topically? Cannabinoids like CBG and CBN can influence the skin microbiome by interacting with the microbial community on the skin’s surface. These cannabinoids have antimicrobial and anti-inflammatory properties that may help balance the skin’s microbiota, potentially reducing harmful bacteria while supporting beneficial microbes. This interaction could enhance the therapeutic effects of cannabinoid patches, especially for conditions like acne or dermatitis, where microbial imbalances contribute to inflammation. The skin microbiome's response to cannabinoids may also influence how cannabinoids are absorbed and metabolized.

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