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How do CBD and THC impact the expression of genes involved in the regulation of pain in chronic pain patients?

How do CBD and THC impact the expression of genes involved in the regulation of pain in chronic pain patients? CBD and THC impact gene expression related to pain regulation by modulating the endocannabinoid system and influencing transcription factors like NF-κB. THC directly activates CB1 and CB2 receptors, which can downregulate genes involved in pain perception and inflammation. CBD supports this process by inhibiting enzymes like FAAH, which increases endocannabinoid levels, and by modulating TRPV1 receptors linked to pain signaling. Together, they alter the expression of pro-inflammatory cytokines and pain-related pathways, reducing chronic pain. This synergy leads to more effective and targeted pain relief in patients with chronic conditions.
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