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How do different types of cannabinoids (e.g., CBD, CBG, CBN) compare in terms of their ability to permeate the skin in patch formulations?

How do different types of cannabinoids (e.g., CBD, CBG, CBN) compare in terms of their ability to permeate the skin in patch formulations? CBD, CBG, and CBN differ in their molecular size, polarity, and lipid solubility, which all influence their ability to permeate the skin. CBD is generally more lipophilic and thus more likely to penetrate the skin’s lipid barrier, while CBG and CBN may require different formulations or enhancers to improve absorption. CBG and CBN might have different therapeutic effects, such as anti-inflammatory or analgesic properties, but their absorption may be slower or less efficient than CBD. Formulating patches to optimize cannabinoid absorption ensures maximum therapeutic benefit.

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