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How does the combination of CBD and THC modulate the release of pro-inflammatory cytokines in the body’s immune system?

How does the combination of CBD and THC modulate the release of pro-inflammatory cytokines in the body’s immune system? CBD and THC suppress pro-inflammatory cytokines such as IL-6, TNF-alpha, and IL-1β through CB2 receptor activation and NF-kB pathway inhibition. CBD’s anti-inflammatory action is enhanced by its antioxidant properties, while THC reduces immune cell activation and cytokine production. Together, they restore immune homeostasis, reducing chronic inflammation in autoimmune and inflammatory diseases. This synergy makes them valuable for managing conditions like rheumatoid arthritis and inflammatory bowel diseases. Their combined effects provide a comprehensive anti-inflammatory approach.
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