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How does the Endocannabinoid System regulate immune system function?

How does the Endocannabinoid System regulate immune system function? The Endocannabinoid System regulates immune system function primarily through the CB2 receptors, which are abundant in immune cells. When activated, CB2 receptors modulate immune responses, including inflammation and immune cell activation. Endocannabinoids like 2-AG and anandamide bind to these receptors to reduce excessive inflammation and maintain immune system balance. This regulation helps prevent chronic inflammation, autoimmune disorders, and tissue damage. By fine-tuning immune responses, the Endocannabinoid System ensures proper defense against pathogens without causing excessive damage to healthy tissues.
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