What factors influence the absorption and metabolism of cannabinoids in different individuals?
What factors influence the absorption and metabolism of cannabinoids in different individuals? Several factors influence the absorption and metabolism of cannabinoids in individuals, including genetics, body composition, route of administration, and concurrent medications. Genetic variations in metabolic enzymes, such as cytochrome P450, can affect how cannabinoids are processed in the liver, leading to differences in efficacy and potential side effects. Additionally, body fat percentage and distribution may impact the distribution of lipophilic cannabinoids, influencing their effects. The route of administration, whether inhalation, oral, or topical, also plays a crucial role in the onset and intensity of cannabinoid effects. Understanding these individual factors is essential for optimizing cannabinoid therapies and personalizing treatment approaches (Huestis, 2007).