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What is the difference between THC and CBD in terms of Endocannabinoid System interaction?

What is the difference between THC and CBD in terms of Endocannabinoid System interaction? The main difference between THC and CBD in terms of Endocannabinoid System interaction lies in their binding affinity and effects on cannabinoid receptors. THC binds directly to CB1 receptors in the brain, producing psychoactive effects like euphoria and altered cognition. CBD, on the other hand, has a weaker affinity for CB1 receptors and does not produce a high. Instead, CBD modulates the ECS by enhancing the effects of endocannabinoids, inhibiting enzymes like FAAH, and influencing CB2 receptors. This results in therapeutic effects like anti-inflammatory, analgesic, and anxiolytic properties without the psychoactive effects of THC.
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