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Hvad er begrænsningerne ved at bruge cannabinoidplastre til kroniske tilstande, der kræver langvarig behandling?

Hvad er begrænsningerne ved at bruge cannabinoidplastre til kroniske tilstande, der kræver langvarig behandling? Potentielle begrænsninger omfatter hudirritation, begrænset cannabinoidbelastningskapacitet og variation i individuelle hudabsorptionshastigheder. Klæbetræthed og reduceret effektivitet over længere slidtider kan påvirke ensartet dosering. Omkostningerne ved transdermale formuleringer af høj kvalitet kan også være en barriere for langvarig brug. Strategier såsom roterende applikationssteder og optimering af formuleringsstabilitet kan hjælpe med at løse disse udfordringer (Giacoppo et al., 2014).

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