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Hvordan påvirker CBD og THC aktiviteten af enzymer involveret i lægemiddelmetabolisme, især CYP450-enzymer i leveren?

Hvordan påvirker CBD og THC aktiviteten af ​​enzymer involveret i lægemiddelmetabolisme, især CYP450-enzymer i leveren? CBD og THC hæmmer begge CYP450-enzymer, hvilket ændrer metabolismen af ​​mange lægemidler. CBD's stærkere hæmmende effekt på CYP3A4 og CYP2C19 kan forlænge aktiviteten af ​​samtidig administreret medicin. THC interagerer også med CYP2C9, påvirker dets egen nedbrydning og forstærker dets psykoaktive virkninger. Sammen kræver de omhyggelig dosisjustering, når de bruges sammen med anden medicin for at undgå interaktioner. Dette understreger behovet for klinisk overvågning i polyfarmaci scenarier.
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