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Kako THC utječe na regulaciju apetita kroz interakcije s neuronima hipotalamusa?

Kako THC utječe na regulaciju apetita kroz interakcije s neuronima hipotalamusa? THC stupa u interakciju s CB1 receptorima u hipotalamusu, regiji mozga koja je uključena u regulaciju apetita, energetske ravnoteže i načina hranjenja. Aktivacija ovih receptora putem THC-a potiče otpuštanje neurotransmitera koji potiču glad i povećavaju unos hrane, što je fenomen poznat kao munchies. THC također utječe na otpuštanje grelina, hormona koji potiče apetit. Ovi učinci su korisni za pacijente koji su podvrgnuti kemoterapiji ili one s poremećajima prehrane, ali u drugim kontekstima, učinci THC-a na poticanje apetita mogli bi doprinijeti prejedanju ili debljanju. Razumijevanje ovih putova može pomoći u razvoju tretmana za regulaciju apetita koji se temelje na kanabisu.

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