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Kako THC utječe na serotonergičke i noradrenergičke sustave u mozgu?

Kako THC utječe na serotonergičke i noradrenergičke sustave u mozgu? THC utječe na serotonergički sustav tako što se veže na 5-HT receptore, posebno na 5-HT1A receptor, što može utjecati na raspoloženje i anksioznost. THC može povećati otpuštanje serotonina, pridonoseći osjećaju euforije, ali u nekim slučajevima može dovesti do tjeskobe ili paranoje zbog promjena u razinama serotonina. Dodatno, THC stupa u interakciju s noradrenergičkim sustavom, utječući na otpuštanje norepinefrina, što utječe na budnost, reakcije na stres i kognitivne funkcije. Ove interakcije igraju ulogu u modulaciji raspoloženja i odgovora na stres tijekom konzumiranja kanabisa. Ravnoteža između ovih sustava može objasniti zašto neki korisnici osjećaju olakšanje od tjeskobe, dok drugi prijavljuju negativne učinke poput povećane paranoje.

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